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September 4, 2025Open Access

Supplementary Fig S1 from PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response

Trisiani Affandi Angela M. Ohm Jordan T. Speidel M. Cecilia Caino Dillon P. Boulton Mary E. Reyland

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Key Points

PKCδ regulates both DNA damage and cell death through antioxidant pathways.
Key interactions involve SIRT6 and Nrf2, critical for cellular responses to stress.
Observational analysis highlights the role of PKCδ in regulating stress response mechanisms.
This work may enable new therapeutic strategies targeting oxidative stress in cells.

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Implication

Observational analysis reveals PKCδ influences DNA damage and cell death mechanisms, suggesting new therapeutic targets.

Abstract

Expressions of PKCδ in shδ cell lines.

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Cite This Study

Affandi et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a061490d https://doi.org/10.1158/1541-7786.30050551

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Fig S4 from PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response2025
2Supplementary Fig S3 from PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response2025
3Supplementary Fig S5 from PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response2025
4Supplementary Fig S2 from PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response2025
5Data from PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response2025

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