Supplementary Fig S5 from PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response

Trisiani Affandi; Angela M. Ohm; Jordan T. Speidel; M. Cecilia Caino; Dillon P. Boulton; Mary E. Reyland

doi:10.1158/1541-7786.30050539

September 4, 2025Open Access

Supplementary Fig S5 from PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response

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Key Points

SIRT6 enhances transcription of Nrf2-targeted genes, promoting antioxidant response in cells.
Depletion of PKCδ leads to increased expression of Nrf2-targeted genes, indicating a regulatory role.
The study focuses on ParC5 cells, providing insights into the molecular mechanisms of cell death.
Antioxidant response mediated by SIRT6 indicates potential therapeutic targets for DNA damage influence.

Implication

Observational analysis reveals SIRT6 influences Nrf2-related gene expression in PKCδ-depleted cells, suggesting a key role in oxidative stress response.

Abstract

SIRT6 upregulates the transcription of Nrf2-targeted genes in ParC5 cells depleted of PKCδ.

Discussion

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Cite This Study

Affandi et al. (2025) studied this question.

synapsesocial.com/papers/68c18f2a9b7b07f3a0615412 https://doi.org/10.1158/1541-7786.30050539

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Supplementary Fig S5 from PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Fig S5 from PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response

Key Points

Implication

Abstract

Discussion

Cite This Study

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