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September 4, 2025Open Access

Supplementary Fig S2 from PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response

Trisiani Affandi Angela M. Ohm Jordan T. Speidel M. Cecilia Caino Dillon P. Boulton Mary E. Reyland

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Key Points

Depletion of PKCδ increases reactive oxygen species (ROS), indicating a possible oxidative stress mechanism.
Cells with PKCδ depletion show decreased DNA damage, suggesting protective cellular responses.
Research indicates that SIRT6 and Nrf2 are potentially involved in mediating the antioxidant response.
Findings highlight the complexity of PKCδ's role in regulating oxidative stress and DNA integrity.

Implication

Depletion of PKCδ reduces DNA damage while increasing ROS in ParC5 and HEK293 cells, suggesting antioxidant mechanisms involving SIRT6 and Nrf2.

Abstract

Depletion of PKCδ increases ROS but decreases DNA damage in ParC5 and HEK293 cells.

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Cite This Study

Affandi et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a0614975 https://doi.org/10.1158/1541-7786.30050548

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