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September 4, 2025Open Access

Supplementary Fig S3 from PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response

Trisiani Affandi Angela M. Ohm Jordan T. Speidel M. Cecilia Caino Dillon P. Boulton Mary E. Reyland

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Key Points

Reduced oxidative DNA damage occurs with depletion of PKCδ in A549 cells, promoting cell survival.
Depletion of PKCδ leads to lowered oxidative DNA damage by acting through SIRT6 and Nrf2 pathways.
Using cellular models, the impact of PKCδ on DNA damage and cell death was assessed effectively.
This research supports targeting PKCδ as a strategy to enhance antioxidant responses in cancer therapies.

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Implication

Depletion of PKCδ reduces oxidative damage and enhances cell survival in A549 cells, suggesting therapeutic potential.

Abstract

Depletion of PKCδ reduces oxidative DNA damage in A549 cells.

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Cite This Study

Affandi et al. (2025) studied this question.

synapsesocial.com/papers/68c18f2a9b7b07f3a0615323 https://doi.org/10.1158/1541-7786.30050545

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Fig S2 from PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response2025
2Supplementary Fig S4 from PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response2025
3Supplementary Fig S5 from PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response2025
4Supplementary Fig S1 from PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response2025
5Data from PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response2025

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