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September 4, 2025Open Access

Supplementary Fig S4 from PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response

Trisiani Affandi Angela M. Ohm Jordan T. Speidel M. Cecilia Caino Dillon P. Boulton Mary E. Reyland

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Key Points

Depletion of PKCδ increases enzymes related to GSH production, promoting an antioxidant response.
Key finding indicates a direct relationship between PKCδ depletion and enhanced GSH enzyme expression.
The study utilized HEK293 cells to examine the role of PKCδ in DNA damage and cell death.
These results suggest potential therapeutic targets for enhancing antioxidant responses in cell injury.

Implication

Depletion of PKCδ influences GSH-related enzymes in HEK293 cells, suggesting antioxidant interplay.

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Cite This Study

Affandi et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a0614929 https://doi.org/10.1158/1541-7786.30050542

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Fig S2 from PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response2025
2Supplementary Fig S3 from PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response2025
3Supplementary Fig S5 from PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response2025
4Supplementary Fig S1 from PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response2025
5Data from PKCδ Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response2025

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