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September 10, 2025Pediatric Blood & Cancer

Multiple Hematopoietic Stem Cell Transplantations in Pediatric Acute Myeloid Leukemia: Prognostic Significance of Remission and Severe Sinusoidal Obstruction Syndrome

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Authors

HYHideki YoshidaSt. Marianna University School of Medicine SIShotaro IwamotoMie University ASAkira ShimadaJichi Medical University

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Implication

Retrospective analysis evaluates overall survival in pediatric AML patients post multiple HSCTs, indicating remission and severe SOS are critical prognostic factors.

Key Points

Achieving hematological complete remission before the second HSCT significantly improves overall survival.
Five-year overall survival after the second HSCT stands at 28.3% among patients, with severe sinusoidal obstruction syndrome worsening prognosis.
Retrospective, multicenter study of 49 pediatric patients with AML conducted over 19 years provides essential insights into outcome predictors.
Optimized pre-transplant strategies are crucial to reduce complications like severe SOS in young patients undergoing multiple HSCTs.

Cite This Study

Yoshida et al. (2025) studied this question.

synapsesocial.com/papers/68c199da9b7b07f3a061b115 https://doi.org/10.1002/pbc.32036

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Implication

Retrospective analysis evaluates overall survival in pediatric AML patients post multiple HSCTs, indicating remission and severe SOS are critical prognostic factors.

Multiple Hematopoietic Stem Cell Transplantations in Pediatric Acute Myeloid Leukemia: Prognostic Significance of Remission and Severe Sinusoidal Obstruction Syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

Multiple Hematopoietic Stem Cell Transplantations in Pediatric Acute Myeloid Leukemia: Prognostic Significance of Remission and Severe Sinusoidal Obstruction Syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

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