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October 2, 2025British Journal of HaematologyOpen Access

Outcomes after a second allogeneic haematopoietic stem cell transplant for relapsed paediatric acute myeloid leukaemia improved over time: A study from the EBMT Paediatric Diseases Working Party

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Authors

NBNimrod BuchbinderVMV. MichelADArnaud Dalissier

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Overview

Analysis reveals enhanced survival metrics in paediatric patients undergoing repeated transplant procedures, suggesting beneficial outcomes with specific conditions.

Key Points

  • Leukaemia-free survival improved significantly over time, with a 3-year rate reaching 34.3% for transplants from 2014-2022.
  • Overall survival rates also saw an enhancement of 10.1 percentage points for HSCT performed in the later period compared to earlier years.
  • Certain factors like remission pre-HSCT2 and later relapse led to better outcomes, highlighting specific patient criteria for successful treatment.
  • Mismatched unrelated donor scenarios adversely affected overall survival, emphasizing the importance of donor compatibility.

Cite This Study

Buchbinder et al. (2025) studied this question.

synapsesocial.com/papers/68de84bf5b556a9128e1bbd2https://doi.org/10.1111/bjh.70167
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia2026
  2. 2Multiple Hematopoietic Stem Cell Transplantations in Pediatric Acute Myeloid Leukemia: Prognostic Significance of Remission and Severe Sinusoidal Obstruction Syndrome2025
  3. 3Continuously improving outcome over time after second allogeneic stem cell transplantation in relapsed acute myeloid leukemia - an EBMT registry analysis of 1540 patients2024
  4. 4The outcome of relapsed childhood acute lymphoblastic leukemia after allogeneic hematopoietic stem‐cell transplantations: A single‐center experience2024 · 3 citations
  5. 5Improving outcomes of hematopoietic stem cell transplant for leukemia in children and young adults in resource-limited setting2024 · 4 citations