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March 21, 2026Pediatric Blood & CancerOpen Access

A PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia

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Authors

AMAva MommUniversitätsklinikum WürzburgIHImme HaubitzUniversity of WürzburgRBRita Beier

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Implication

Retrospective multicenter analysis examines survival and relapse rates in pediatric acute lymphoblastic leukemia, suggesting important factors for patient outcomes.

Key Points

  • This study aims to identify prognostic factors that influence survival and relapse rates in pediatric patients undergoing a second allogeneic hematopoietic stem cell transplantation.
  • Conducted a retrospective multicenter analysis of 75 pediatric patients from the PRSZT registry.
  • Analyzed transplant outcomes for those who underwent second HSCT between 2011 and 2020.
  • Employed univariate and multivariate analysis to identify predictors of survival and relapse.
  • Overall survival at 2 and 5 years was 48% and 40%, respectively.
  • Relapse-free survival at 2 and 5 years was 35.2% and 29.9%, respectively.
  • Chronic graft-versus-host disease after HSCT2 improved overall survival and relapse-free survival.
  • Older age and precursor T-cell ALL were linked to poorer overall and relapse-free survival.

Cite This Study

Momm et al. (2026) studied this question.

synapsesocial.com/papers/69be36086e48c4981c674ab5https://doi.org/10.1002/1545-5017.70263
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  5. 5Prognostic factors for survival in children who relapsed after allogeneic hematopoietic stem cell transplantation for acute leukemia2020 · 8 citations