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November 18, 2025British Journal of HaematologyOpen Access

Outcomes and risk factors of second allogeneic haematopoietic stem cell transplantation in patients with relapsed haematological malignancy after first transplantation

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Authors

XZXiaolu ZhuHFHaixia FuJLJing Liu

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Overview

Retrospective cohort study reveals poor overall survival in relapsed hematological malignancy patients after second transplantation, indicating the need for improved prognostic factors.

Key Points

  • The study aims to evaluate outcomes and risk factors of second allogeneic haematopoietic stem cell transplantation in relapsed hematological malignancies.
  • Retrospective cohort study of 58 patients undergoing second allo-HSCT.
  • Analysis of treatment-related mortality, overall survival, and disease-free survival rates after transplantation.
  • Assessment of factors contributing to patient outcomes such as age and initial remission duration.
  • Overall survival (OS) at one year was 52.1%.
  • Disease-free survival at one year was reported at 46.5%.
  • Cumulative incidence of relapse was 21.8% post second transplantation.

Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/6924feebc0ce034ddc3519b9https://doi.org/10.1111/bjh.70259
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1How risky is a second allogeneic stem cell transplantation?2024 · 18 citations
  2. 2Disease Status and Interval between Hematopoietic Cell Transplantations Predict Outcome of Pediatric Patients Who Undergo Subsequent Transplantation for Relapsed Hematologic Malignancy2024 · 2 citations
  3. 3Good report of secondary allogeneic hematopoietic stem cell transplantation in patients with refractory/relapsed Acute Myeloid Leukemia2025
  4. 4The outcome of relapsed childhood acute lymphoblastic leukemia after allogeneic hematopoietic stem‐cell transplantations: A single‐center experience2024 · 3 citations
  5. 5A PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia2026