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December 8, 2025BloodOpen Access

Good report of secondary allogeneic hematopoietic stem cell transplantation in patients with refractory/relapsed Acute Myeloid Leukemia

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Authors

TWTong WuQWQi WangYZYongqiang Zhao

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Overview

Randomised trial shows leukemia survival rates after secondary HSCT in patients with refractory AML, suggesting effective intervention options.

Key Points

  • The study aims to evaluate the effectiveness of secondary allogeneic HSCT in patients with refractory or relapsed acute myeloid leukemia.
  • Enrolled 43 patients with AML from April 2018 to April 2023.
  • Administered secondary allogeneic HSCT with conditioning regimens including TBI plus fludarabine/cladribine or BU plus fludarabine/cladribine.
  • Assessed post-transplant complications and hematopoietic reconstitution.
  • Achieved a 2-year overall survival rate of 46.4% post-secondary HSCT.
  • Noted a 2-year cumulative recurrence rate of 35.1%.
  • Patients achieving CR showed higher post-transplant OS rates.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e2eahttps://doi.org/10.1182/blood-2025-7795
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Retrospective, single-center analysis of second allogeneic stem cell transplantation versus non-transplant regimens for acute myeloid leukemia patients with relapse after first transplantation2026
  2. 2Outcomes and risk factors of second allogeneic haematopoietic stem cell transplantation in patients with relapsed haematological malignancy after first transplantation2025
  3. 3Late Relapse after Allogeneic Stem Cell Transplantation in Patients Treated for Acute Myeloid Leukemia: Relapse Incidence, Characteristics, Role of Conditioning Regimen, and Outcome2024 · 10 citations
  4. 4Outcomes after a second allogeneic haematopoietic stem cell transplant for relapsed paediatric acute myeloid leukaemia improved over time: A study from the <scp>EBMT</scp> Paediatric Diseases Working Party2025 · 1 citations
  5. 5Multiple Hematopoietic Stem Cell Transplantations in Pediatric Acute Myeloid Leukemia: Prognostic Significance of Remission and Severe Sinusoidal Obstruction Syndrome2025