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September 10, 2025Open Access

Phospholipids that plug the pores of cholesteryl ester transfer protein control its lipid transfer dynamics

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Authors

SSSukriti SacherPSPraveen SinghAMAbhishek Mukherjee

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Overview

Analysis shows lipid movement in cholesteryl ester transfer protein, revealing phospholipids regulate lipid transfer dynamics.

Key Points

  • CETP-bound phospholipids play a crucial role in enhancing lipid movement through its central tunnel.
  • Molecular dynamics simulations demonstrate that phospholipids enable optimal CETP tunnel architecture for lipid traversal.
  • The study identifies regulatory mechanisms involving phenylalanine flaps that prevent lipid backflow during transport.
  • Insights into the phospholipid interplay with CETP advance understanding of lipid transfer mechanisms in cardiovascular health.

Cite This Study

Sacher et al. (2025) studied this question.

synapsesocial.com/papers/68c199e29b7b07f3a061b47dhttps://doi.org/10.1101/2025.09.04.674379
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Also Consider

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  3. 3Phospholipid and cholesteryl ester transfer are increased in lipoprotein lipase deficiency2003 · 12 citations
  4. 4Lipoprotein lipase requires a flexible lid and stable C-terminal, both maintained by ApoC-II peptide binding2025
  5. 5Decoding Structural Fingerprints to Design and Elucidate the Mechanism of Action of Prospective Cholesteryl Ester Transfer Protein Drugs2025