The efficacy and safety of transcatheter aortic valve replacement in elderly patients with aortic stenosis

Background: Transcatheter aortic valve replacement (TAVR) is a promising treatment for aortic stenosis (AS). However, few clinical studies have concentrated on the application of TAVR in elderly AS patients. This study aimed to explore the efficacy and safety of TAVR in elderly patients with AS.Methods: Clinical and imaging data of 143 AS patients undergoing Transcatheter aortic valve replacement were retrospectively analyzed. These patients were divided into non-elderly group (< 65 years old) and elderly group (65 years old), and the baseline characteristics and clinical outcomes were compared between the two groups.Results: The baseline characteristics showed no significant difference between the two groups. After surgery, echocardiography revealed that the forward flow velocity of aortic valve was higher in the non-elderly group than that in the elderly group (234.2 49.8 cm/s vs. 209.957.7 cm/s, P=0.022), while there was no significant difference in other indicators. The operation time (197.463.5 min vs. 194.267.8 min, P=0.811), length of hospital stay (14.07.3 days vs.14.27.6 days, P=0.874), incidence of perioperative complications (2.2% vs. 4.1%, P=1.000), and mortality rate (0.0% vs. 1.0%, P=1.000) sho wed no significant differences between the two groups.Conclusion: Transcatheter aortic valve replacement is an effective and safe therapeutic approach for elderly patients with aortic stenosis.