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September 10, 2025International Journal of Reproduction Contraception Obstetrics and GynecologyOpen Access

Efficacy of levonorgestrel releasing intrauterine system in the treatment of symptomatic adenomyosis: comparison with dienogest

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Authors

SSSharmin SultanaAdvanced Fiber Technologies (United States)PCPriyanka ChowdhuryUniversity of DhakaRRRafikunnahar RenuBangabandhu Sheikh Mujib Medical University

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Implication

Randomized trial shows LNG-IUS reduces menstrual pain in women with adenomyosis, suggesting improved outcomes over dienogest.

Key Points

  • LNG-IUS significantly reduced menstrual pain compared to dienogest at 3 and 6 months follow-ups.
  • In the LNG-IUS group, hemoglobin levels improved significantly more by 6 months, indicating better overall health.
  • Women on LNG-IUS reported regular menstrual flow more frequently, while heavy bleeding persisted in the dienogest group.
  • Adverse effects were more common in the dienogest group, though not statistically significant.

Cite This Study

Sultana et al. (2025) studied this question.

synapsesocial.com/papers/68c1a25354b1d3bfb60dcd9dhttps://doi.org/10.18203/2320-1770.ijrcog20252324
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-term efficacy and feasibility of levonorgestrel-releasing intrauterine device use in patients with adenomyosis2020 · 25 citations
  2. 2The role of levonorgestrel intra‐uterine system in the management of adenomyosis: A systematic review and meta‐analysis of prospective studies2019 · 65 citations
  3. 3Efficacy and safety of dienogest in patients with endometriosis: A single-center observational study over 12 months2016 · 75 citations
  4. 4Randomised comparative trial of the intrauterine system and norethisterone levonor gestrel for treatment of idiopathic menorrhagia1998 · 270 citations
  5. 5A controlled clinical trial comparing potent progestins, LNG‐IUS and dienogest, for the treatment of women with adenomyosis2021 · 35 citations