What question did this study set out to answer?

The aim is to compare the effects of LNG-IUS and DNG on systemic inflammatory markers and anemia parameters after 6 months of treatment.

February 22, 2026International Journal of Gynecology & Obstetrics

Comparison of the effects of levonorgestrel‐releasing intrauterine system and dienogest treatment on systemic inflammatory markers ( NLR , PLR , SII ) and anemia parameters in patients with adenomyosis at 6 months

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Authors

MPMehmet Emre PekerSivas State Hospital DKDuygu Uçar KartalState Hospital UAUfuk Atlıhan

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Implication

This cohort study compares the effects of LNG-IUS and DNG on inflammatory markers in women with adenomyosis, suggesting distinct impacts on hemoglobin levels.

Key Points

The aim is to compare the effects of LNG-IUS and DNG on systemic inflammatory markers and anemia parameters after 6 months of treatment.
Retrospective longitudinal observational cohort study
Included 162 women diagnosed with adenomyosis
89 patients received LNG-IUS; 73 received DNG 2 mg/day
Measured hemoglobin, neutrophil, lymphocyte, and platelet counts at baseline and 6 months
Statistical analyses conducted using SPSS 27.0 with significance at P < 0.05.
Hemoglobin levels increased more in the LNG-IUS group (2.29 ± 3.61) compared to the DNG group (0.84 ± 4.82; P = 0.035)
No significant differences in neutrophil, lymphocyte, or platelet counts between groups before and after treatment (P > 0.05)
Both treatments were safe and effective for adenomyosis management
Inflammatory indices (NLR, PLR, SII) showed limited sensitivity in reflecting short-term response.

Cite This Study

Peker et al. (2026) studied this question.

synapsesocial.com/papers/699a9d27482488d673cd2e06 https://doi.org/10.1002/ijgo.70903

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Implication

This cohort study compares the effects of LNG-IUS and DNG on inflammatory markers in women with adenomyosis, suggesting distinct impacts on hemoglobin levels.

Comparison of the effects of levonorgestrel‐releasing intrauterine system and dienogest treatment on systemic inflammatory markers ( NLR , PLR , SII ) and anemia parameters in patients with adenomyosis at 6 months

Discussion

Member takes

Implication

Key Points

Cite This Study

Comparison of the effects of levonorgestrel‐releasing intrauterine system and dienogest treatment on systemic inflammatory markers ( NLR , PLR , SII ) and anemia parameters in patients with adenomyosis at 6 months

Discussion

Member takes

Implication

Key Points

Cite This Study

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