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September 10, 2025American Journal of Translational Research

Mechanical thrombectomy combined with tirofiban for treatment of acute intracranial atherosclerotic cerebral infarction: clinical observations and effect on serum inflammatory factors

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Authors

BCBen-Yang ChenYBYuzhang BeiJCJ F Chen

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Overview

Retrospective analysis confirms mechanical thrombectomy with tirofiban improves revascularization and reduces inflammatory factors in patients with cerebral infarction.

Key Points

  • After treatment, the revascularization rate was significantly higher in the observation group at 94.12%.
  • Post-treatment inflammatory factors including hs-CRP and TNF-α showed significant reduction in the observation group, improving patient outcomes.
  • Logistic analysis indicated that NIHSS score post-treatment is an independent risk factor for re-occlusion.
  • The combined approach of tirofiban with MT significantly improved neurological function scores, indicating enhanced recovery.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68c1c23554b1d3bfb60efa1ahttps://doi.org/10.62347/fjgc1286
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Safety and Efficacy of Intra-arterial Tirofiban Injection During Mechanical Thrombectomy for Large Artery Occlusion2019 · 23 citations
  2. 2Association of tirofiban with improvement of functional outcomes of direct thrombectomy for acute anterior circulation occlusion: a retrospective, nonrandomized, multicenter, real-world study2023 · 3 citations
  3. 3Tirofiban influences serum inflammatory factors and neurotransmitter levels in acute cerebral infarction patients2024
  4. 4Evaluation of safety and efficacy of Tirofiban injection for treating acute ischemic stroke beyond standard time window2025 · 2 citations
  5. 5ABSTRACT NUMBER: ESOC2026A1519 INVESTIGATING THE SAFETY AND EFFICACY OF PERIPROCEDURAL TIROFIBAN USE IN MECHANICAL THROMBECTOMY2026