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September 10, 2025

Bio-synthesis of TiO2 and Ag-TiO2 nanoparticles using Aegle marmelos seed extract and their potential efficacy investigation in human leukemic cell proliferation, inflammation and oxidative stress

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Authors

ATAsma TabassumUniversity of KarachiVDVishwajit Basavaraj DarekarGulbarga UniversityBIBasawarajeshwari IndurGulbarga University

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Overview

Bio-functionalized TiO2 and Ag-TiO2 nanoparticles reduce inflammation and oxidative stress in leukemic cells, indicating potential therapeutic uses.

Key Points

  • TiO2 and Ag-TiO2 nanoparticles exhibit significant anti-cancer effects, reducing cell proliferation and enhancing apoptosis.
  • Ag-TiO2 nanoparticles show enhanced cytotoxicity with an IC50 of 27.65µg/ml compared to 151.3µg/ml for TiO2 nanoparticles.
  • The study utilized various characterization methods including UV-Vis spectroscopy and SEM-EDX to analyze nanoparticle properties.
  • Both nanoparticles led to significant reductions in inflammatory markers and oxidative stress, highlighting their therapeutic potential.

Cite This Study

Tabassum et al. (2025) studied this question.

synapsesocial.com/papers/68c1c31254b1d3bfb60f06c6https://doi.org/10.21203/rs.3.rs-7045921/v1
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