What does this research mean for the field?

Ag/TiO₂ bimetallic nanoparticles synthesized using Couroupita guianensis extracts demonstrate significant in vitro antidiabetic, anti-inflammatory, antibacterial, and antioxidant activities. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To synthesize Ag/TiO₂ bimetallic nanoparticles using Couroupita guianensis extracts and evaluate their computational, antibacterial, antidiabetic, and anti-inflammatory properties.

August 23, 2026BioNanoScienceOpen Access

Sustainable Synthesis of Ag/TiO₂ Bimetallic Nanoparticles with Enhanced Antidiabetic and Anti-Inflammatory Properties: A Combined Experimental and Computational Analysis

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Authors

SPS. PonmaniDepartment of Biotechnology PSP. SrinivasanDepartment of Biotechnology SSS. SudhakarSaveetha University

Discussion

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Implication

In vitro and in silico study demonstrates antidiabetic and anti-inflammatory efficacy of plant-synthesized Ag/TiO₂ nanoparticles, suggesting potential for multifunctional therapeutics.

Key Points

To synthesize Ag/TiO₂ bimetallic nanoparticles using Couroupita guianensis extracts and evaluate their computational, antibacterial, antidiabetic, and anti-inflammatory properties.
Synthesized Ag/TiO₂ nanoparticles using leaf and flower extracts of Couroupita guianensis, followed by characterization via TEM, XRD, FTIR, and zeta potential.
Performed in silico molecular docking and molecular dynamics simulations to analyze interactions between plant phytochemicals and α-amylase.
Assessed antioxidant, antibacterial (Escherichia coli and Staphylococcus aureus), α-amylase inhibition, and anti-inflammatory activities across triplicate experimental runs.
Flower-mediated nanoparticles achieved 56.87 ± 1.42% α-amylase inhibition at 100 µg/mL compared to 50.92 ± 1.18% for leaf-mediated nanoparticles (p < 0.05), alongside significantly greater antioxidant and antibacterial activity (p < 0.05).
Leaf-mediated nanoparticles exhibited 73.61 ± 1.26% anti-inflammatory activity at 10 µg/mL, compared to 71.61 ± 1.34% for flower-mediated nanoparticles.
Molecular docking identified β-Amyrin palmitate (−8.1 kcal/mol) and Farnesol (−6.6 kcal/mol) as stable α-amylase inhibitors through molecular dynamics confirmation.

Cite This Study

Ponmani et al. (2026) studied this question.

synapsesocial.com/papers/6a8aad857677a34114445aae https://doi.org/10.1007/s12668-026-02793-1

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August 23, 2026BioNanoScienceOpen Access

Sustainable Synthesis of Ag/TiO₂ Bimetallic Nanoparticles with Enhanced Antidiabetic and Anti-Inflammatory Properties: A Combined Experimental and Computational Analysis

View Full Paper

Ask AI

Bookmark

Authors

SPS. PonmaniDepartment of Biotechnology PSP. SrinivasanDepartment of Biotechnology SSS. SudhakarSaveetha University

Discussion

Member takes

Implication

In vitro and in silico study demonstrates antidiabetic and anti-inflammatory efficacy of plant-synthesized Ag/TiO₂ nanoparticles, suggesting potential for multifunctional therapeutics.

Key Points

To synthesize Ag/TiO₂ bimetallic nanoparticles using Couroupita guianensis extracts and evaluate their computational, antibacterial, antidiabetic, and anti-inflammatory properties.
Synthesized Ag/TiO₂ nanoparticles using leaf and flower extracts of Couroupita guianensis, followed by characterization via TEM, XRD, FTIR, and zeta potential.
Performed in silico molecular docking and molecular dynamics simulations to analyze interactions between plant phytochemicals and α-amylase.
Assessed antioxidant, antibacterial (Escherichia coli and Staphylococcus aureus), α-amylase inhibition, and anti-inflammatory activities across triplicate experimental runs.
Flower-mediated nanoparticles achieved 56.87 ± 1.42% α-amylase inhibition at 100 µg/mL compared to 50.92 ± 1.18% for leaf-mediated nanoparticles (p < 0.05), alongside significantly greater antioxidant and antibacterial activity (p < 0.05).
Leaf-mediated nanoparticles exhibited 73.61 ± 1.26% anti-inflammatory activity at 10 µg/mL, compared to 71.61 ± 1.34% for flower-mediated nanoparticles.
Molecular docking identified β-Amyrin palmitate (−8.1 kcal/mol) and Farnesol (−6.6 kcal/mol) as stable α-amylase inhibitors through molecular dynamics confirmation.

Cite This Study

Ponmani et al. (2026) studied this question.

synapsesocial.com/papers/6a8aad857677a34114445aae https://doi.org/10.1007/s12668-026-02793-1

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