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September 10, 2025Organic & Biomolecular Chemistry

RuII-amidobis(phosphine) catalyzed alkylation of indole and epoxide opening followed by α-alkylation through alcohol oxidation

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Authors

SSSachin C. SonawaneBKBhupinder KaurHAHanshika Arya

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Overview

Microwave-assisted technique enables gram-scale alkylation of indoles and epoxide opening, suggesting economic viability for broader applications.

Key Points

  • The method achieves gram-scale C3-alkylation of indoles with high efficiency, demonstrating practical application.
  • Using microwave assistance, the approach effectively facilitates epoxide opening and subsequent α-alkylation in one setup.
  • This catalytic strategy utilizes RuII for efficient transformations, showcasing its versatility in synthetic organic chemistry.
  • The findings indicate potential cost benefits, as the process is designed to be economically viable for large-scale synthesis.

Cite This Study

Sonawane et al. (2025) studied this question.

synapsesocial.com/papers/68c1d80554b1d3bfb60fa8a6https://doi.org/10.1039/d5ob00937e
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