RuII-amidobis(phosphine) catalyzed alkylation of indole and epoxide opening followed by α-alkylation through alcohol oxidation

Sachin C. Sonawane; Bhupinder Kaur; Hanshika Arya; Rani Gourkhede; Maravanji S. Balakrishna

doi:10.1039/d5ob00937e

January 1, 2025Organic & Biomolecular Chemistry

RuII-amidobis(phosphine) catalyzed alkylation of indole and epoxide opening followed by α-alkylation through alcohol oxidation

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Key Points

The method achieves gram-scale C3-alkylation of indoles with high efficiency, demonstrating practical application.
Using microwave assistance, the approach effectively facilitates epoxide opening and subsequent α-alkylation in one setup.
This catalytic strategy utilizes RuII for efficient transformations, showcasing its versatility in synthetic organic chemistry.
The findings indicate potential cost benefits, as the process is designed to be economically viable for large-scale synthesis.

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Implication

Microwave-assisted technique enables gram-scale alkylation of indoles and epoxide opening, suggesting economic viability for broader applications.

Abstract

Herein, we report a simple, microwave assisted and open-air strategy for gram-scale C3-alkylation of indoles, along with an economically viable strategy for epoxide opening followed by α-alkylation, using the [RuIICl(bpy){o-Ph2PC6H4CONC6H4PPh2-o}-κ5-(P,N,P,N,N)]...

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Sonawane et al. (2025) studied this question.

synapsesocial.com/papers/68c1d80554b1d3bfb60fa8a6 https://doi.org/10.1039/d5ob00937e

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RuII-amidobis(phosphine) catalyzed alkylation of indole and epoxide opening followed by α-alkylation through alcohol oxidation

Key Points

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Implication

Abstract

Discussion

Cite This Study

RuII-amidobis(phosphine) catalyzed alkylation of indole and epoxide opening followed by α-alkylation through alcohol oxidation

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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