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September 15, 2025

Supplementary Figure 4 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control

Helen Hockings Eszter Lakatos Weini Huang Maximilian Mossner Mohammed A. Khan Nikolina Bakali Jacqueline McDermott Kane Smith Ann‐Marie Baker Trevor A. Graham Michelle Lockley

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Key Points

The study achieves long-term tumor control using adaptive therapy in chemotherapy-resistant ovarian cancer.
Cell imaging revealed changes in confluence levels with different FBS concentrations over 120 hours in N=4 experiments.
Assessment utilized a brightfield microscope, enabling observation every four hours during the experiment.
These findings suggest adaptive therapy may be a viable strategy for managing chemotherapy-resistant ovarian tumors.

Implication

Experimental analysis demonstrates tumor control in ovarian cancer cells, highlighting adaptive therapy's potential benefits.

Abstract

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Cite This Study

Hockings et al. (2025) studied this question.

synapsesocial.com/papers/68d4508931b076d99fa58889 https://doi.org/10.1158/0008-5472.30125905

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 6 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
2Supplementary Figure 8 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
3Supplementary Figure 5 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
4Supplementary Figure 1 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
5Figure 5 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025

Supplementary Figure 7 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
Figure 3 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
Figure 6 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025