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This is a Quantitative Study study.

September 16, 2025CancersOpen Access

The EBV-Positive Tumor Methylome Is Distinct from EBV-Negative in Diffuse Large B-Cell Lymphoma

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EBV(+) diffuse large B-cell lymphoma shows a distinct, hypermethylated DNA methylome compared to EBV(−) cases, indicating significant epigenetic differences.
A total of 117,334 differentially methylated probes linked to cancer-associated genes were identified in EBV(+) DLBCL relative to EBV(−), suggesting biomarkers for disease classification.
Differential methylation analyses revealed unique biological pathways in EBV(+) DLBCL, including alterations in P53 and MAPK signaling pathways.
These findings may aid in understanding the clinical heterogeneity of DLBCL and contribute to therapeutic targeting strategies.

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Global methylome analysis reveals hypermethylated and hypomethylated profiles in EBV(+) DLBCL, suggesting distinct disease mechanisms.

Volaric et al. (2025) studied this question.

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