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Case Report: Coronary vasospasm precipitating STEMI and polymorphic ventricular tachycardia—a case of cardiotoxicity from 5-FU based chemotherapy in a 41-year-old woman

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Case report reveals coronary vasospasm causing STEMI and arrhythmia in a patient treated with FOLFOX, suggesting need for monitoring.

Coronary vasospasm led to significant cardiac events, including STEMI and polymorphic ventricular tachycardia.
The patient experienced symptoms just three days after initiating FOLFOX chemotherapy based on 5-fluorouracil.
Monitoring and treatment with calcium channel blockers and nitrates were effective in managing the patient's condition.
Successful rechallenge with chemotherapy highlights the need for awareness of potential cardiovascular effects of 5-FU.

Hasnie et al. (2025) studied this question.

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