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September 17, 2025GenesOpen Access

Hi-C Technology Reveals Actionable Gene Fusions and Rearrangements in Diffuse Large B-Cell Lymphoma Unidentified by Conventional FISH

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Authors

SLSichen LiangCACandice AmentMKMelanie Klausner

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Overview

Hi-C technology reveals actionable gene fusions in diffuse large B-cell lymphoma, suggesting superior diagnostic potential over FISH.

Key Points

  • Hi-C detected structural variations that conventional FISH missed, enhancing diagnostic accuracy for lymphoma.
  • In five cases, new translocation partners and genomic events were identified, highlighting the assay's comprehensive capabilities.
  • The Hi-C assay employed high-resolution sequencing from formalin-fixed paraffin-embedded samples for genome mapping.
  • This improved detection approach supports better personalized treatment strategies for complex lymphoma cases.

Cite This Study

Liang et al. (2025) studied this question.

synapsesocial.com/papers/68d45b3431b076d99fa5dd00https://doi.org/10.3390/genes16091093
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