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December 8, 2025BloodOpen Access

Application of hi-c sequencing to detect cryptic and novel structural aberrations in lymphoid neoplasms

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Authors

DKDeepika KumarDBDemetrios T. Braddock

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Overview

Hi-C sequencing reveals cryptic genomic aberrations in lymphoid malignancies, suggesting enhanced diagnostic precision.

Key Points

  • This research aims to highlight the utility of Hi-C sequencing in identifying cryptic structural aberrations in lymphoid neoplasms.
  • Analyzed unstained FFPE tissue sections from lymphoma cases using Arima Hi-C analysis.
  • Extracted nucleic acids and sequenced ligated DNA fragments for genome-wide mapping of genetic loci.
  • Employed a bioinformatics pipeline to detect structural rearrangements and genomic aberrations.
  • Identified a cryptic IGH-MYC rearrangement in a case of Burkitt lymphoma, influencing treatment decisions.
  • Revealed structural rearrangements involving BCL3 and confirmed FISH results in a case of high-grade B-cell lymphoma.
  • Detected multiple genomic deletions and rearrangements in a case of diffuse large B-cell lymphoma, guiding therapy.

Cite This Study

Kumar et al. (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e139https://doi.org/10.1182/blood-2025-4355
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hi-C Technology Reveals Actionable Gene Fusions and Rearrangements in Diffuse Large B-Cell Lymphoma Unidentified by Conventional FISH2025 · 2 citations
  2. 2Application of Hi-C sequencing to detect oncogene rearrangements for diagnosis and treatment of large B-cell lymphoma2026
  3. 3Clinical use of genome-wide hi-c sequencing for assessment of structural variants in diffuse large B-cell lymphoma2025
  4. 4Hi-C for genome-wide detection of enhancer-hijacking rearrangements in routine lymphoid cancer biopsies2026 · 3 citations
  5. 5Comprehensive genomic profiling of diffuse large B cell lymphoma using targeted NGS: Insights into MYC, BCL2, and BCL6 rearrangements and beyond2025 · 1 citations