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June 19, 2026Blood AdvancesOpen Access

Application of Hi-C sequencing to detect oncogene rearrangements for diagnosis and treatment of large B-cell lymphoma

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Authors

ZXZijun Y. Xu‐MonetteCWChang Wang吴吴得红

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Overview

Randomized trial demonstrates high sensitivity and specificity of Hi-C sequencing for lymphoma diagnosis, indicating improved treatment options.

Key Points

  • This study aims to evaluate Hi-C sequencing for detecting oncogene rearrangements in diffuse large B-cell lymphoma (DLBCL).
  • Conducted Hi-C sequencing on FFPE tissues from 159 DLBCL patients.
  • Identified a total of 746 cancer genes at rearrangement breakpoints with 1903 occurrences.
  • Used machine learning models for survival analysis of genome-wide rearrangements.
  • Hi-C detected 102 clinically significant rearrangements in 92 patients, including 25 missed by FISH.
  • Identified 22 rearrangements in 20 patients (12.6%) that were characteristic of other lymphoma types.
  • Found significant prognostic effects of rearrangements such as MYC, BCL2, and CCND1 in the patient cohort.

Cite This Study

Xu‐Monette et al. (2026) studied this question.

synapsesocial.com/papers/6a34de4165a5b0777af2db04https://doi.org/10.1182/bloodadvances.2026019675
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hi-C Technology Reveals Actionable Gene Fusions and Rearrangements in Diffuse Large B-Cell Lymphoma Unidentified by Conventional FISH2025 · 2 citations
  2. 2Clinical use of genome-wide hi-c sequencing for assessment of structural variants in diffuse large B-cell lymphoma2025
  3. 3Application of hi-c sequencing to detect cryptic and novel structural aberrations in lymphoid neoplasms2025
  4. 4Hi-c FFPE sequencing analysis is highly concordant with FISH and detects additional variants informing diagnosis and treatment in diffuse large B-cell lymphoma2025
  5. 5Hi-C for genome-wide detection of enhancer-hijacking rearrangements in routine lymphoid cancer biopsies2026 · 3 citations