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December 8, 2025BloodOpen Access

Hi-c FFPE sequencing analysis is highly concordant with FISH and detects additional variants informing diagnosis and treatment in diffuse large B-cell lymphoma

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Authors

ATAlexandar TzankovACApril ChiuMXMina L. Xu

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Overview

Hi-C sequencing detects more genomic rearrangements in non-Hodgkin lymphoma, suggesting improved clinical decision-making and targeted therapies.

Key Points

  • To compare Hi-C sequencing with FISH analysis in identifying genomic rearrangements in diffuse large B-cell lymphoma (DLBCL).
  • Hi-C sequencing of FFPE samples from 159 DLBCL patients
  • Comparison of Hi-C results with standard FISH analysis
  • Assessment of additional biomarkers beyond FISH panel
  • Hi-C detected 102 out of 105 key biomarkers while FISH detected 80
  • Hi-C identified 5 double-hit lymphomas compared to 4 by FISH
  • Additional biomarkers relevant for diagnosis were found in 42 cases (26%)

Cite This Study

Tzankov et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e577https://doi.org/10.1182/blood-2025-3529
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