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The Hyperglycemic Hyperosmolar Syndrome: History and Essential Clinical Insights

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Hyperglycemic hyperosmolar state can have a mortality rate up to 20%, requiring urgent medical attention.
Classic symptoms include excessive thirst, polyuria, and altered mental status, especially during infections or in poorly controlled diabetes.
Rapid diagnostic evaluation and prompt treatment initiation can significantly reduce morbidity and mortality in acute cases.
Increased awareness among healthcare professionals about hyperglycemic hyperosmolar state is crucial for timely intervention.

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This review explores hyperglycemic hyperosmolar state in diabetes, highlighting critical management strategies and rising prevalence.

Maciejewski et al. (2025) studied this question.

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