Key result
Patients with isolated hyperglycemic hyperosmolar syndrome had a significantly higher 30-day mortality rate (26.0%) compared to those with mixed diabetic ketoacidosis and HHS (0%).
Why the study?
Despite advances in diabetes management, the clinical features and outcomes of patients with hyperglycemic hyperosmolar syndrome remain unclear.
Population
84 consecutive patients diagnosed with HHS at a university hospital in Japan
Comparison
Isolated HHS vs mixed DKA/HHS, and isolated HHS with vs without metabolic acidosis
Design
Retrospective cohort study
Follow-up
30 days
Authors
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Isolated HHS with acidosis signals high short-term mortality; leaves open whether targeted interventions improve outcomes in elderly patients.
Cohort (n=84)
No
Absolute Event Rate: 26% vs 0%
p-value: p=0.0452
Isolated hyperglycemic hyperosmolar syndrome, particularly when accompanied by metabolic acidosis other than ketoacidosis, is associated with high 30-day mortality in elderly patients.
Fujiya et al. (2025) conducted a cohort in Hyperglycemic hyperosmolar syndrome (HHS) (n=84). Isolated HHS vs. Mixed DKA/HHS was evaluated on 30-day mortality (p=0.0452). Patients with isolated hyperglycemic hyperosmolar syndrome had a significantly higher 30-day mortality rate (26.0%) compared to those with mixed diabetic ketoacidosis and HHS (0%).
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