What question did this study set out to answer?

To investigate the clinical characteristics, precipitating factors, and in-hospital outcomes of adult patients hospitalized with diabetic ketoacidosis or hyperglycemic hyperosmolar syndrome in acute care settings.

January 31, 2023Open Access

Clinical profile of patients with diabetic ketoacidosis and hyperglycemic hyperosmolar syndrome in Japan: A multicenter retrospective cohort study

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Authors

KTKyosuke Takahashi NUNorimichi Uenishi MSMasamitsu Sanui

Discussion

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Overview

Retrospective cohort study reveals in-hospital mortality of 2.8% for diabetic ketoacidosis and 7.1% for hyperosmolar syndrome in adults, indicating lower hyperosmolar syndrome deaths than expected.

Key Points

To investigate the clinical characteristics, precipitating factors, and in-hospital outcomes of adult patients hospitalized with diabetic ketoacidosis or hyperglycemic hyperosmolar syndrome in acute care settings.
Multicenter retrospective cohort study conducted across 21 acute care hospitals in Japan.
Identified 771 hospitalized adults (aged ≥18 years) with diabetic ketoacidosis (n=545) or hyperglycemic hyperosmolar syndrome (n=226) between January 1, 2012, and December 31, 2016.
Extracted clinical features from medical records and compared outcomes across four severity groups: mild DKA, moderate DKA, severe DKA, and HHS.
In-hospital mortality was 2.8% in patients with diabetic ketoacidosis and 7.1% in patients with hyperglycemic hyperosmolar syndrome, with no significant difference observed across DKA severity groups.
Median hospital stay was 16 days (IQR 10–26 days) overall and was longer in the HHS group (19.5 days) than the DKA groups (16 days), with a mean intensive care unit admission rate of 44.4%.
Common complications included infection (18%), pulmonary edema (2.7%), stroke (2.1%), ventricular arrhythmia (1.6%), and deep vein thrombosis (1%).

Cite This Study

Takahashi et al. (2023) studied this question.

synapsesocial.com/papers/6a72844cf44fa9f079dff8a3 https://doi.org/10.21203/rs.3.rs-2467653/v1

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January 31, 2023Open Access

Clinical profile of patients with diabetic ketoacidosis and hyperglycemic hyperosmolar syndrome in Japan: A multicenter retrospective cohort study

View Full Paper

Ask AI

Bookmark

Authors

KTKyosuke Takahashi NUNorimichi Uenishi MSMasamitsu Sanui

Discussion

Member takes

Overview

Retrospective cohort study reveals in-hospital mortality of 2.8% for diabetic ketoacidosis and 7.1% for hyperosmolar syndrome in adults, indicating lower hyperosmolar syndrome deaths than expected.

Key Points

To investigate the clinical characteristics, precipitating factors, and in-hospital outcomes of adult patients hospitalized with diabetic ketoacidosis or hyperglycemic hyperosmolar syndrome in acute care settings.
Multicenter retrospective cohort study conducted across 21 acute care hospitals in Japan.
Identified 771 hospitalized adults (aged ≥18 years) with diabetic ketoacidosis (n=545) or hyperglycemic hyperosmolar syndrome (n=226) between January 1, 2012, and December 31, 2016.
Extracted clinical features from medical records and compared outcomes across four severity groups: mild DKA, moderate DKA, severe DKA, and HHS.
In-hospital mortality was 2.8% in patients with diabetic ketoacidosis and 7.1% in patients with hyperglycemic hyperosmolar syndrome, with no significant difference observed across DKA severity groups.
Median hospital stay was 16 days (IQR 10–26 days) overall and was longer in the HHS group (19.5 days) than the DKA groups (16 days), with a mean intensive care unit admission rate of 44.4%.
Common complications included infection (18%), pulmonary edema (2.7%), stroke (2.1%), ventricular arrhythmia (1.6%), and deep vein thrombosis (1%).

Cite This Study

Takahashi et al. (2023) studied this question.

synapsesocial.com/papers/6a72844cf44fa9f079dff8a3 https://doi.org/10.21203/rs.3.rs-2467653/v1

View Full Paper

Ask AI

Bookmark