Why the study?
Current knowledge of hyperosmolar hyperglycaemic state is drawn from case series and small observational cohorts, and a lack of robust, large-scale studies exploring triggers and associated mortality impedes prevention strategies and clinical guidelines.
What are the precipitants, outcomes, and regional variations associated with hyperosmolar hyperglycaemic state?
Population
63 935 HHS cases across 27 studies
Design
Systematic review and meta-analysis
Authors
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Regional HHS mortality varies widely (4.8–40%); supports targeted prevention but leaves open optimal protocols pending prospective trials.
What are the precipitants, outcomes, and regional variations associated with hyperosmolar hyperglycaemic state?
Hyperosmolar hyperglycaemic state carries a high overall mortality of 21.1%, with significant global disparities in outcomes and resource utilization.
French et al. (2026) studied this question.
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