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This review highlights the link between aberrant tissue factor and cardiovascular diseases, suggesting it may be a target for treating various conditions.
Tissue Factor (TF) is the initiator of the coagulation cascade, however if aberrantly expressed can result in pro-thrombotic action. Indeed, aberrant expression has been linked to untoward outcomes such as cardiovascular risks, hypercoagulability often observed in many clinical conditions which expands its role in proinflammation, diabetes, obesity, cardiovascular diseases, angiogenesis, tumor metastasis including ovarian cancer progression, endometriosis progression and many others, making this molecule a possible target for disease treatment.
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Graciela Krikun (2023) studied this question.
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