Preclinical evaluation shows enhanced antitumor response in osteosarcoma using Folate Receptor-α CART cells, suggesting potential for pediatric cancer treatment.
FOLR1 expression by osteosarcoma from various genomic databases. A, mRNA expression of FOLR1 in various pediatric malignancies from the St. Jude PCGP database. Increased FOLR1 mRNA expression demonstrated in osteosarcoma, as well as other solid tumors such as ependymoma and renal cell carcinoma. Line across denotes median FPKM. B, Data obtained from the PIVOT demonstrate high FOLR1 mRNA expression by osteosarcoma in addition to ependymoma. Line across denotes median TPM. C, Data obtained from the Open Pediatric Cancer Project v15 shows increased FOLR1 mRNA expression by osteosarcoma, ependymoma, renal cell carcinoma, and choroid plexus carcinoma. Line across denotes median TPM. ALL, acute lymphoblastic leukemia.
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Choe et al. (2025) studied this question.
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