Table S10 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

Asael Roichman; Gabriela Reyes‐Castellanos; Ziqing Chen; Zihong Chen; Sarah J. Mitchell; Michael R. MacArthur; Akshada Sawant; Llewelyn Levett; Jesse R. Powers; Victoria Burgo; Maria Gomez-Jenkins; Maria Ibrahim; Xincheng Xu; Beianka Tomlinson; Xiang Hang; Eric G. Pamer; Yong Wei; Yibin Kang; Eileen White; Joshua D. Rabinowitz

doi:10.1158/0008-5472.30210050

Key Points

Dietary fiber shows no consistent effect on immune checkpoint blockade efficacy across models, suggesting further investigation is necessary.
The analysis of fecal metabolites highlighted variability in response to dietary fiber, emphasizing the need for individualized dietary approaches.
Using diverse murine tumor models, the study employed metabolic profiling to assess the impact of dietary fiber on treatment outcomes.
The findings may enable a better understanding of how dietary interventions can influence immune responses in cancer treatment.

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Implication

Observational analysis reveals dietary fiber lacks consistent effects on immune checkpoint blockade efficacy, indicating potential variability across murine tumor models.

Abstract

Fecal metabolite peak areas from the YUMM1.1-9 model

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Roichman et al. (2025) studied this question.

synapsesocial.com/papers/68d7b3ddeebfec0fc52366ee https://doi.org/10.1158/0008-5472.30210050

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Table S10 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Table S10 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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