Table S6 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

Asael Roichman; Gabriela Reyes‐Castellanos; Ziqing Chen; Zihong Chen; Sarah J. Mitchell; Michael R. MacArthur; Akshada Sawant; Llewelyn Levett; Jesse R. Powers; Victoria Burgo; Maria Gomez-Jenkins; Maria Ibrahim; Xincheng Xu; Beianka Tomlinson; Xiang Hang; Eric G. Pamer; Yong Wei; Yibin Kang; Eileen White; Joshua D. Rabinowitz

doi:10.1158/0008-5472.30029842

Key Points

Inconsistent effects of dietary fiber on immune checkpoint blockade efficacy were observed across various murine tumor models, indicating variability.
The analysis used serum metabolite peak areas from the YUMM1.1-9 model to examine how dietary fiber interacts with tumor treatment.
Across different tumor models, dietary fiber did not show a consistent effect on enhancing immune checkpoint blockade efficacy during treatment.
Findings highlight the need for further investigation into the role of diet in cancer treatment, particularly with immune checkpoint inhibitors.

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Implication

Observational analysis reveals inconsistent effects of dietary fiber on immune checkpoint blockade efficacy in murine tumor models, suggesting complexity in dietary impacts.

Abstract

Serum metabolite peak areas from the YUMM1.1-9 model

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Roichman et al. (2025) studied this question.

synapsesocial.com/papers/68bb5f076d6d5674bcd02b63 https://doi.org/10.1158/0008-5472.30029842

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Table S6 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

Key Points

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Implication

Abstract

Discussion

Cite This Study

Table S6 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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