Table S6 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

Asael Roichman; Gabriela Reyes‐Castellanos; Ziqing Chen; Zihong Chen; Sarah J. Mitchell; Michael R. MacArthur; Akshada Sawant; Llewelyn Levett; Jesse R. Powers; Victoria Burgo; Maria Gomez-Jenkins; Maria Ibrahim; Xincheng Xu; Beianka Tomlinson; Xiang Hang; Eric G. Pamer; Yong Wei; Yibin Kang; Eileen White; Joshua D. Rabinowitz

doi:10.1158/0008-5472.30028691

Key Points

No consistent effect of dietary fiber on immune checkpoint blockade efficacy was observed across various tumor models.
Key evidence suggests varied responses in tumor models, highlighting the complex relationship between diet and immunotherapy.
The analysis utilized serum metabolite peak areas from the YUMM1.1-9 model to assess effects on immunity.
Findings call for further exploration of dietary variables in cancer therapies across diverse preclinical settings.

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Implication

Observational analysis reveals no consistent impact of dietary fiber on immune blockade efficacy in murine tumor models, suggesting variability in dietary influences.

Abstract

Serum metabolite peak areas from the YUMM1.1-9 model

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Roichman et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd02924 https://doi.org/10.1158/0008-5472.30028691

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Table S6 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Table S6 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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