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September 25, 2025Open Access

Table S7 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

Asael Roichman Gabriela Reyes‐Castellanos Ziqing Chen Zihong Chen Sarah J. Mitchell Michael R. MacArthur Akshada Sawant Llewelyn Levett Jesse R. Powers Victoria Burgo Maria Gomez-Jenkins Maria Ibrahim Xincheng Xu Beianka Tomlinson Xiang Hang Eric G. Pamer Yong Wei Yibin Kang Eileen White Joshua D. Rabinowitz

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Key Points

Dietary fiber showed no consistent effect on immune checkpoint blockade efficacy across various murine tumor models, indicating complexity in interactions.
Evaluation of serum metabolite peak areas using the PyMT model provided key insights into the metabolic responses involved in treatment.
Observational analysis across several murine tumor models highlighted the variability in immune responses to dietary fiber supplementation.
Results may enable better understanding of nutritional impacts on cancer immunotherapy, emphasizing the need for further research.

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Implication

Analysis reveals dietary fiber lacks consistent effects on immune checkpoint blockade efficacy in murine models, suggesting complex interactions.

Abstract

Serum metabolite peak areas from the PyMT model

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Cite This Study

Roichman et al. (2025) studied this question.

synapsesocial.com/papers/68d913b24ddcf71ba560c16a https://doi.org/10.1158/0008-5472.30210026

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Table S7 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models2025
2Table S7 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models2025
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Table S6 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models2025
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