Automated heparin-resistant recalcifying solution improves lupus anticoagulant detection using chronometric assays, indicating more reliable results in heparinized patients.
The International Society on Thrombosis and Haemostasis (ISTH) recommends using two chronometric assays for LA detection: activated partial thromboplastin time (aPTT) and dilute Russell's viper venom time (dRVVT).[1] Laboratories typically use paired assays, combining a screening test, which contains a low concentration of phospholipids, and a confirmation test, containing a higher phospholipids concentration. This pairing is designed to demonstrate the phospholipid dependence of any observed prolongation in clotting time.
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Herb et al. (2025) studied this question.
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