September 28, 2025Clinical Infectious DiseasesOpen Access

Human Cases of Carbapenemase-Producing Escherichia coli Linked to Spread Between Animals and the Environment in a Veterinary Facility -Massachusetts, USA, 2023

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Investigation finds genetic linkage of blaNDM-5-carrying E. coli between humans and animals, suggesting risk to human health.

WGS revealed genetic clustering among human, animal, and environmental isolates, indicating potential transmission.
Initial interviews failed to find links, but follow-up questions revealed all patients had pets treated at the same veterinary hospital.
Investigative efforts included environmental screening and whole genome sequencing to understand this emerging health threat.
The findings highlight the need for a One Health approach to manage CPE transmission from animals to humans.

DeStefano et al. (2025) studied this question.

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