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September 28, 2025Magnesium Research

Serum magnesium concentration: time for a standardised and evidence-based reference range

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Authors

HWHeike WeißerKlinikum FuldaKKKlaus KistersKlinik und Poliklinik für Psychosomatik und PsychotherapieJVJürgen VormannInstitut für Prävention und Nachsorge

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Implication

Proposal for a standardized reference range for serum magnesium levels, highlighting risks associated with low magnesium.

Key Points

  • Raising the lower limit of serum magnesium to 0.85 mmol/L may reduce disease risk, including diabetes and cardiovascular issues.
  • Current reference intervals show significant laboratory variation, with many below the proposed threshold of 0.85 mmol/L.
  • A literature search in PubMed supports the need for evidence-based reference ranges for serum magnesium.
  • Standardizing serum magnesium levels in labs could improve diagnostic importance alongside other electrolytes.

Cite This Study

Weißer et al. (2024) studied this question.

synapsesocial.com/papers/68d8f313d88e2624dc4c5725https://doi.org/10.1684/mrh.2025.0548
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A-045 Serum Magnesium Levels: A Comparative Study of Reference Values2025
  2. 2Serum Magnesium Concentrations in the United States—An Updated Population Reference Interval in Children and Adults2026 · 2 citations
  3. 3Why Serum Magnesium Fails: A Narrative Review of Magnesium Biochemistry, Compartmental Exchange, and Endpoint Selection for Supplementation Trials2026
  4. 4Serum magnesium and risk of hyperglycemia, type 2 diabetes, and prediabetes: a systematic review and dose-response meta-analysis of observational studies2026
  5. 5Serum Magnesium and the Risk of Death From Coronary Heart Disease and Sudden Cardiac Death2016 · 151 citations