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September 29, 2025Open Access

Outdoor Air Pollution, Perivascular Space Morphology, and Cognition in Preadolescence

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Authors

JMJessica MorrelKSKirthana SukumaranCTCarinna M. Torgerson

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Overview

Cross-sectional analysis shows outdoor air pollution affects perivascular spaces and cognition in children, indicating potential neurodevelopmental risks.

Key Points

  • Higher exposure to outdoor air pollution correlates with increased perivascular space count and poorer cognitive performance.
  • Positive associations were found between zinc, ammonium, and bromine exposure with perivascular space count in brain regions.
  • PM2.5 mixtures were linked to impaired working memory and crystallized intelligence in preadolescents.
  • Increased frontal lobe perivascular space count mediated the relationship between zinc exposure and reduced total cognition.

Cite This Study

Morrel et al. (2025) studied this question.

synapsesocial.com/papers/68da58d8c1728099cfd1113ehttps://doi.org/10.1101/2025.09.26.678867
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sources of outdoor air pollution exposure and child brain network development across the United States2025
  2. 2Ambient pollution components and sources are associated with hippocampal architecture and memory in pre-adolescents2026
  3. 3Exposure to multiple ambient air pollutants changes white matter microstructure during early adolescence with sex-specific differences2024 · 13 citations
  4. 4Residential Ambient Air Pollution Exposure and the Development of White Matter Microstructure Throughout Adolescence.2024 · 12 citations
  5. 5Prenatal and childhood air pollution exposure, cellular immune biomarkers, and brain connectivity in early adolescents2024 · 9 citations