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October 18, 2025Hypertension

Abstract FR575: Exposure to Air Pollution Associated to Reduced Brain Volume in Young Adolescents, Mediated by Hypertension

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Authors

JGJ. Dixon GrayCambridge University Hospitals NHS Foundation TrustMNMarcus Vinícius Nascimento‐FerreiraUniversidade Federal do TocantinsEHEthan T. HuntThe University of Texas Health Science Center at Houston

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Implication

Statistical analysis reveals air pollution decreases brain volume in adolescents, suggesting hypertension plays a mediating role.

Key Points

  • Exposure to air pollution is negatively correlated with brain volume in adolescents aged 10 to 14.
  • The total effect of PM 2.5 on brain volume was found to be -28.88, indicating significant negative impact.
  • Hypertension was identified as a significant mediator between air pollution exposure and decreased brain volume.
  • Data was analyzed from the Adolescent Brain Cognitive Development study across 21 research sites in the U.S.

Cite This Study

Gray et al. (2025) studied this question.

synapsesocial.com/papers/68f3b2fb3f213c1f8b4d36a7https://doi.org/10.1161/hyp.82.suppl_1.fr575
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Also Consider

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  1. 1Outdoor Air Pollution, Perivascular Space Morphology, and Cognition in Preadolescence2026 · 2 citations
  2. 2Exposure to multiple ambient air pollutants changes white matter microstructure during early adolescence with sex-specific differences2024 · 30 citations
  3. 3Residential ambient air pollution exposure and the development of white matter microstructure throughout adolescence2024 · 13 citations
  4. 4Ambient pollution components and sources are associated with hippocampal architecture and memory in pre-adolescents2026
  5. 5The Impact of Early Life Exposure to Air Pollution on the Brain: A Diffusion MRI Study in 10–13‐Year‐Old Children With and Without ADHD Diagnosis2025 · 6 citations