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June 12, 2026BMC MedicineOpen Access

Ambient pollution components and sources are associated with hippocampal architecture and memory in pre-adolescents

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Authors

MRMichael A. RosarioKSKirthana SukumaranKBKatherine L. Bottenhorn

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Overview

Randomized trial investigates how pollution impacts hippocampal architecture and memory in pre-adolescents, highlighting critical emission sources.

Key Points

  • Examine the relationship between ambient air pollution exposure and hippocampal structure and memory in pre-adolescents.
  • Analyzed data from 7,940 participants in the Adolescent Brain Cognitive Development Study.
  • Used partial least squares correlation to assess multi-pollutant exposure effects on the hippocampus.
  • Adjusted models for demographic, socioeconomic, and neuroimaging factors.
  • PM 2.5 total mass was associated with hippocampal microstructure; no effect on long-axis volume or list-learning ability.
  • Higher exposures to bromine, sulfate, and vanadium were linked to changes in microstructure; copper and zinc associated with smaller hippocampal volumes.
  • Pollution sources such as biomass burning and traffic were implicated in hippocampal structure alterations.

Cite This Study

Rosario et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba5068101cf8926f032e7https://doi.org/10.1186/s12916-026-04950-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Outdoor Air Pollution, Perivascular Space Morphology, and Cognition in Preadolescence2025
  2. 2Sources of outdoor air pollution exposure and child brain network development across the United States2025
  3. 3Abstract FR575: Exposure to Air Pollution Associated to Reduced Brain Volume in Young Adolescents, Mediated by Hypertension2025
  4. 4Exposure to multiple ambient air pollutants changes white matter microstructure during early adolescence with sex-specific differences2024 · 13 citations
  5. 5Prenatal and childhood air pollution exposure, cellular immune biomarkers, and brain connectivity in early adolescents2024 · 9 citations