Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 2025Medical Journal of BabylonOpen Access

In Vitro Antiproliferative Effect of the Whole Extract and Serine Protease of Lumbricus terrestris on the MCF-7 Cell Line

View Full Paper
Ask AI
Bookmark
Share

Authors

AQAyman Abdel Salam QassemFSFarha A. Ali ShafiNFNebrass Faleh

Discussion

Loading...

Member takes

Overview

In vitro analysis shows antiproliferative activity of Lumbricus terrestris extracts and serine protease against MCF-7 cells, indicating potential cancer treatments.

Key Points

  • The study found that crude extracts of Lumbricus terrestris significantly inhibited MCF-7 cell proliferation, revealing their antiproliferative potential.
  • The extracts demonstrated weak cytotoxicity with IC50 values of 228 μg/ml for MCF-7 cells and 319 μg/ml for normal NHF cells.
  • Serine protease isolated from earthworms exhibited moderate cytotoxicity against both MCF-7 and NHF cell lines, with IC50 values ranging from 21-200 μg/ml.
  • These findings support the potential use of earthworm extracts and enzymes as therapeutic agents in anticancer treatments.

Cite This Study

Qassem et al. (2025) studied this question.

synapsesocial.com/papers/68dd91dafe798ba2fc499540https://doi.org/10.4103/mjbl.mjbl_973_23
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antitumor Activity of Serine Enzyme and Crude Extracts of The Earthworm Lumbricus terrestris Against A549 Human Lung Cancer Cell Line2024 · 1 citations
  2. 2Unveiling the Phytochemical Profile and Anti‐Cancer Potential of <scp><i>Lantana camara</i></scp> Leaf and Root Extracts Against <scp>MCF</scp>‐7, <scp>HepG2</scp>, and <scp>A549</scp> Cancer Cell Lines2025 · 2 citations
  3. 3Cytotoxic effect of Luffa cylindrica leaf extract on MCF-7 cell lines2025
  4. 4Evaluation of the anticancer potential of Pleurotus eous against human breast cancer MCF-7 cell line2026
  5. 5Partially Purified Polysaccharides from Lentinus edodes (Mushroom) Scavenge Free Radicals and Induce Apoptosis in MCF-7 Cancer Cells by Regulating Apoptotic Genes2024 · 1 citations