Supplementary Figure S2 from Molecular Characterization of Residual Muscle-Invasive Bladder Cancer Identifies a Scar-Like Transcriptomic Profile with Favorable Prognosis after Neoadjuvant Therapy

Q: What type of study is this?

This is a Quantitative Study study.

Joep J. de Jong; Moritz J. Reike; Yair Lotan; Roland Seiler; Elai Davicioni; Andrea Necchi; Thomas Powles; Peter C. Black; Bernadett Szabados; Ewan A. Gibb

doi:10.1158/1078-0432.30255739

October 1, 2025Open Access

Supplementary Figure S2 from Molecular Characterization of Residual Muscle-Invasive Bladder Cancer Identifies a Scar-Like Transcriptomic Profile with Favorable Prognosis after Neoadjuvant Therapy

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Key Points

Identifying a scar-like transcriptomic profile indicates favorable prognosis after therapy.
High signature scores in gene expressions like TGF-beta and FGFR3 correlate with positive outcomes.
Utilizing gene expression profiling, biological clusters were defined from cystectomy samples treated with atezolizumab.
Findings emphasize the role of angiogenesis and apoptosis pathways in bladder cancer recovery.

Implication

Gene expression profiling reveals favorable prognosis in bladder cancer after neoadjuvant therapy, highlighting biological clusters.

Abstract

Figure S2. Defining novel biological clusters using gene expression profiling in radical cystectomy samples previously treated with neoadjuvant atezolizumab. Signature scores among ABACUS CC1-4 for (A) TGF-beta, (B) FGFR3 pathway, (C) Angiogenesis, (D) DNA repair, (E) Glycolysis, and (F) Apoptosis.

Discussion

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Cite This Study

Jong et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21921 https://doi.org/10.1158/1078-0432.30255739

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Supplementary Figure S2 from Molecular Characterization of Residual Muscle-Invasive Bladder Cancer Identifies a Scar-Like Transcriptomic Profile with Favorable Prognosis after Neoadjuvant Therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S2 from Molecular Characterization of Residual Muscle-Invasive Bladder Cancer Identifies a Scar-Like Transcriptomic Profile with Favorable Prognosis after Neoadjuvant Therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

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