Supplementary Figure S5 from Molecular Characterization of Residual Muscle-Invasive Bladder Cancer Identifies a Scar-Like Transcriptomic Profile with Favorable Prognosis after Neoadjuvant Therapy

Q: What type of study is this?

This is a Quantitative Study study.

Joep J. de Jong; Moritz J. Reike; Yair Lotan; Roland Seiler; Elai Davicioni; Andrea Necchi; Thomas Powles; Peter C. Black; Bernadett Szabados; Ewan A. Gibb

doi:10.1158/1078-0432.30255730

October 1, 2025Open Access

Supplementary Figure S5 from Molecular Characterization of Residual Muscle-Invasive Bladder Cancer Identifies a Scar-Like Transcriptomic Profile with Favorable Prognosis after Neoadjuvant Therapy

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Key Points

A scar-like transcriptomic profile associates with favorable prognosis in bladder cancer post-therapy.
This analysis displays downregulated genes in consensus stroma-rich tumors, revealing key genetic insights.
The research involves differential gene expression analysis comparing specific tumor types to assess outcomes.
These findings may highlight important implications for targeted treatment strategies in bladder cancer cases.

Implication

Differential gene expression analysis identifies a scar-like profile in bladder cancer tumors, suggesting better prognosis after treatment.

Abstract

Figure S5. Differential gene expression analysis comparing the CC-scar-like to the remaining Consensus stroma-rich tumors. Select downregulated genes have been circled in blue.

Discussion

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Cite This Study

Jong et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a2193d https://doi.org/10.1158/1078-0432.30255730

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Supplementary Figure S5 from Molecular Characterization of Residual Muscle-Invasive Bladder Cancer Identifies a Scar-Like Transcriptomic Profile with Favorable Prognosis after Neoadjuvant Therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S5 from Molecular Characterization of Residual Muscle-Invasive Bladder Cancer Identifies a Scar-Like Transcriptomic Profile with Favorable Prognosis after Neoadjuvant Therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

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