Supplementary Figure S8 from Molecular Characterization of Residual Muscle-Invasive Bladder Cancer Identifies a Scar-Like Transcriptomic Profile with Favorable Prognosis after Neoadjuvant Therapy

Q: What type of study is this?

This is a Quantitative Study study.

Joep J. de Jong; Moritz J. Reike; Yair Lotan; Roland Seiler; Elai Davicioni; Andrea Necchi; Thomas Powles; Peter C. Black; Bernadett Szabados; Ewan A. Gibb

doi:10.1158/1078-0432.30255721

October 1, 2025Open Access

Supplementary Figure S8 from Molecular Characterization of Residual Muscle-Invasive Bladder Cancer Identifies a Scar-Like Transcriptomic Profile with Favorable Prognosis after Neoadjuvant Therapy

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Key Points

Scar-like transcriptomic profiles are associated with favorable outcomes in muscle-invasive bladder cancer after treatment.
Quantitative immunohistochemistry scoring distinguished these scar-like cases from other samples in the ABACUS cohort.
The analysis highlighted the importance of transcriptomic classifiers in predicting prognosis post-neoadjuvant therapy.
The findings underline the potential for tailored treatment approaches based on transcriptomic characterization.

Implication

Analysis reveals scar-like transcriptomic profile linked to favorable prognosis after neoadjuvant therapy in muscle-invasive bladder cancer patients.

Abstract

Figure S8. Comparing quantitative immunohistochemistry (IHC) scores between scar-like cases identified by the transcriptomic classifier (TC) and remaining samples from the ABACUS cohort.

Discussion

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Cite This Study

Jong et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a2195d https://doi.org/10.1158/1078-0432.30255721

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Supplementary Figure S8 from Molecular Characterization of Residual Muscle-Invasive Bladder Cancer Identifies a Scar-Like Transcriptomic Profile with Favorable Prognosis after Neoadjuvant Therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S8 from Molecular Characterization of Residual Muscle-Invasive Bladder Cancer Identifies a Scar-Like Transcriptomic Profile with Favorable Prognosis after Neoadjuvant Therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

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