Supplementary Figure S3 from Molecular Characterization of Residual Muscle-Invasive Bladder Cancer Identifies a Scar-Like Transcriptomic Profile with Favorable Prognosis after Neoadjuvant Therapy

Q: What type of study is this?

This is a Quantitative Study study.

Joep J. de Jong; Moritz J. Reike; Yair Lotan; Roland Seiler; Elai Davicioni; Andrea Necchi; Thomas Powles; Peter C. Black; Bernadett Szabados; Ewan A. Gibb

doi:10.1158/1078-0432.30255736

October 1, 2025

Supplementary Figure S3 from Molecular Characterization of Residual Muscle-Invasive Bladder Cancer Identifies a Scar-Like Transcriptomic Profile with Favorable Prognosis after Neoadjuvant Therapy

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Key Points

Distinct biological clusters identified from gene expression profiling, impacting prognosis significantly.
Analysis of gene markers like KRT5 and CD44 reveals potential for improved outcomes after neoadjuvant therapy.
Method derived from gene expression scores in cystectomy samples, highlighting the role of transcripts in treatment response.
Findings suggest transcriptomic profiles may guide future treatment approaches and patient management in bladder cancer.

Implication

Gene expression analysis from radical cystectomy samples shows distinct biological clusters, suggesting favorable outcomes post-neoadjuvant therapy.

Abstract

Figure S3. Defining novel biological clusters using gene expression profiling in radical cystectomy samples previously treated with neoadjuvant atezolizumab. Gene marker expression scores among ABACUS CC1-4 for (A) KRT5, (B) KRT14, (C) CD44, (D) PPARG, (E) GATA3, (F) KRT20, (G) MYH11, (H) DES, and (I) C7.

Discussion

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Cite This Study

Jong et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a2193b https://doi.org/10.1158/1078-0432.30255736

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Supplementary Figure S3 from Molecular Characterization of Residual Muscle-Invasive Bladder Cancer Identifies a Scar-Like Transcriptomic Profile with Favorable Prognosis after Neoadjuvant Therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S3 from Molecular Characterization of Residual Muscle-Invasive Bladder Cancer Identifies a Scar-Like Transcriptomic Profile with Favorable Prognosis after Neoadjuvant Therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

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