Supplementary Video 8 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells

Chuanjie Zhang; Hongchao He; Yi Gao; Jiawei Ding; Hai Huang; Yixun Liu; Hanqing Liu; Jun Xiao; Dan-feng Xu; Zunguo Du; Zhenbo Zhang; Lechi Ye

doi:10.1158/0008-5472.30255628

October 1, 2025

Supplementary Video 8 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells

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Key Points

bbox1 serves as a metabolic checkpoint, impacting metastatic cancer cell evasion from the immune system.
Live imaging illustrates coculture dynamics between bbox1pos cancer cells and rhoA-knockdown NK92 cells.
Overexpression of wild-type rhoA or the 2A rhoA mutant in the coculture reveals critical mechanisms of evasion.
These findings highlight potential therapeutic strategies to enhance immunosurveillance against metastatic tumors.

Implication

Live imaging highlights a metabolic checkpoint role of bbox1 in metastatic cancer evasion from NK cells, suggesting new therapeutic directions.

Abstract

Live imaging of coculture of RCC108-derived BBOX1pos cells (white border line) and RhoA-knockdown NK92 cells (green border line) with ectopic overexpression of wild-type RhoA or the 2A RhoA mutant (2A mutant).

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Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21974 https://doi.org/10.1158/0008-5472.30255628

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Supplementary Video 8 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Video 8 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

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