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October 1, 2025

Supplementary Video 3 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells

Chuanjie Zhang Hongchao He Yi Gao Jiawei Ding Hai Huang Yixun Liu Hanqing Liu Jun Xiao Dan-feng Xu Zunguo Du Zhenbo Zhang Lechi Ye

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Key Points

BBOX1 acts as a metabolic checkpoint for metastatic cancer cell evasion from nk cells during immunosurveillance.
Live imaging showed the interaction dynamics between nk92 cells and bbox1pos or bbox1neg cancer cells.
This research utilized video microscopy to analyze the coculture of nk cells and cancer cell lines effectively.
Understanding bbox1's role may enhance strategies for improving nk cell-mediated immune responses against tumors.

Implication

Live imaging reveals that bbox1 influences metastatic cancer evasion from nk cells, indicating its role as a crucial checkpoint.

Abstract

Live imaging of coculture of NK92 cells (green border line) and RCC108-derived BBOX1pos or BBOX1neg cells (white border line) using video microscopy.

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Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a2198f https://doi.org/10.1158/0008-5472.30255643

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Video 4 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
2Supplementary Video 1 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
3Supplementary Video 8 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
4Supplementary Video 7 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
5Supplementary Video 5 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025