Supplementary Video 4 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells

Chuanjie Zhang; Hongchao He; Yi Gao; Jiawei Ding; Hai Huang; Yixun Liu; Hanqing Liu; Jun Xiao; Dan-feng Xu; Zunguo Du; Zhenbo Zhang; Lechi Ye

doi:10.1158/0008-5472.30255640

October 1, 2025

Supplementary Video 4 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells

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Key Points

BBOX1 acts as a metabolic checkpoint, enabling metastatic cancer cells to evade NK cell immunity.
Live imaging revealed interactions between NK92 and RCC108-derived cells, showcasing cellular dynamics.
The study focuses on the impact of carnitine on BBOX1 knockdown cells in immune evasion.
This finding opens avenues for targeted therapies against metastatic cancer by modulating NK cell responses.

Implication

Live imaging shows BBOX1's role in metastatic cancer cells evading immunosurveillance by NK cells, suggesting a crucial checkpoint.

Abstract

Live imaging of coculture of NK92 cells (green border line) and RCC108-derived BBOX1pos cells (white border line) with BBOX1 knockdown (BBOX1 KD) when in the absence or presence of carnitine.

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Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21a84 https://doi.org/10.1158/0008-5472.30255640

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Supplementary Video 4 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Video 4 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

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