Live imaging demonstrates BBOX1's role in immune evasion of metastatic cancer cells, suggesting a metabolic checkpoint that may help develop new therapies.
Live imaging of coculture of RCC108-derived BBOX1neg cells (white border line) and Lifeact-GFP-expressing NK92 cells with or without slc22a5 knockdown (sislc22a5) when in the presence or absence of carnitine.
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Zhang et al. (2025) studied this question.
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